[Under threat of lawsuit by "Fraudulent Company" this expert had to beg me to NOT use his name!]
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I have examined the material you sent me entitled “Secret #2″ and “They must dissolve,” copyright 1995 by Fraudulent Companys System. This is some of the most incredible nonsense I have ever encountered. Most of it is incorrect, and much of it is internally inconsistent and self-0contradictory. I will discuss it paragraph by paragraph. First, however, it is important to recognize that what the author describes as di-calcium phosphate is really dibasic calcium phosphate, CaHPO4. There also exist monobasic calcium phosphate, Ca(H2PO4) and tribasic calcium phosphate, Ca3(PO4)2.
Secret #2
Paragraph 1) I have no problem with this.
P 2 & 3) The point of these paragraphs is that dibasic calcium phosphate is a binder with terrible nutritional properties and is poorly absorbed by the body. as you are aware, dibasic calcium phosphate is NOT a binder and has no physical or chemical properties which would make it useful as one. Dibasic calcium phosphate is instead used as a filler, because it is inert, unreactive, and cheap. The zillion other names by which it goes are unfamiliar to me unless the author refers to the other phosphate sales of calcium, as I outlined above, or unless he means various trade names (just as Cheerios are called Cheerios by their manufacturer and not “roasted oats shaped like little doughnuts.”_
Anyway, I know of no manufacturer who deliberately attempts to disguise the use of dibasic calcium phosphate, because it is innocuous. Further, none of the calcium phosphates have any property similar to cement. The only true statement in these paragraphs is that dibasic calcium phosphate is not absorbed well by the body, because it is only very slightly soluble in water or stomach acid. This is why most calcium supplements use calcium carbonate, citrate, or glycerophosphate as calcium sources.
These salts are water soluble and the calcium assimilable, dibasic calcium phosphate is not well absorbed and passes pretty well unchanged through the digestive system.
The author then attributes blocked blood vessels, joint discomfort, kidney stones, gallstones, Alzheimer’s, excess calcium in the hair, improper absorption of other nutrients, and premature aging to the use of dibasic calcium phosphate. All of these conditions are associated with excess concentrations of calcium in various parts of the body beyond the digestive system, with the possible exception of premature aging, whatever that means. But the author can’t possibly have it both ways. Eden Log move
If dibasic calcium phosphate is very poorly soluble, and it is, then how does all this calcium get all through the body?? Into the hair, the kidneys, blood, synovial fluid, gall bladder, brain, etc.?? Why doesn’t it just go right through and be excreted?? Of course, that’s exactly what does happen.
The last part of the 3rd paragraph discusses the “fact” that, since dibasic calcium phosphate is not very soluble it is “incompletely reduced,” and therefore not properly metabolized. This makes no sense. The thermodynamic equilibrium constant for the dissociation of dibasic calcium phosphate controls the extend of dissociation and the amount of free calcium ions released into the stomach; once these ions have dissociated they may be metabolized. There exists absolutely no evidence of any kind in the scientific literature that they end up preferentially in soft tissue sites. The lack of such evidence may explain why the so-called holistic medical community has seen fit to invent the name “blocking agent” to describe behavior which does not occur.
Paragraph 4) As I have explained above, calcium which does not dissolve (in other words, the dibasic calcium phosphate to which the author objects so strongly) cannot reach the arteries to cause arteriosclerotic disease, cannot reach the joints to cause arthritis, and cannot cause wrinkles and premature aging. The second part of the paragraph, which outlines how free phosphate can tie up mineral nutrients and inhibit their absorption, is true, but irrelevant. Dibasic calcium phosphate contains no free phosphate; it is already tied up by the calcium. Just as the calcium in dibasic calcium phosphate is not absorbable because it is complexed by the phosphate; neither is the phosphate free to complex other metal ions, because it is complexed by the calcium.
Paragraph 5) this refers to the various calcium salts I discussed above.
They Must Dissolve
Paragraph 1) Leaving aside the fact that very few people are deficient in stomach acid, and that most tablets do both disintegrate and dissolve, it is certainly true that a tablet which does not disintegrate may not release all its active ingredient. This is why careful formulators include tablet disintegrants in their tablet formulations. The presence or absence of dibasic calcium phosphate has no particular relationship with the dis integration or dissolution time of a tablet formulated with a disintegrant. As a matter of fact, there are some occasions where calcium phosphate sales are added to formulations to make the tablet disintegrate more rapidly.
Further, in this paragraph DCP is called a strong alkalizer, and reference is made to Tums as a well known alkalizing calcium product. Tums contains calcium carbonate not calcium phosphate. The carbonate anion is the alkalizer, as it neutralizes stomach acid. The dibasic phosphoric acid anion exists only between pH 3 and 7 (in acid solution) and will not neutralize acids; carbonate ions exist only above approximately pH 10, in strongly alkaline solution.
Paragraph 2) Studies showing that tablets become harder and disintegrate more slowly as they get older don’t particularly surprise me, but this is true regardless of whether they are formulated using dibasic calcium phosphate or not. There are probably ten other factors which can explain this phenomenon. That’s why most tablets bear an expiration or freshness date.
Paragraph 3) All phosphates won’t. Only water-soluble phosphates, such as sodium or potassium phosphates, or free phosphoric acid, will interfere with the absorption of other mineral nutrients. Because dibasic calcium phosphate is relatively insoluble, the phosphate it contains is unable to react with other minerals.
Paragraph 4) More nonsense. If one wanted to formulate a manganese product containing 30 mg manganese per tablet one would severely endanger is customer, as this is a massive overdose. If one instead was to formulate a 5 mg manganese tablet weight 700 mg he would probably use 10 mg manganese carbonate (which is about 50% manganese by weight), about 140 mg microcrystalline cellulose as a binder, 520 mg dibasic calcium phosphate (which contains only 150 mg calcium, not 300) as a filler, and 20 mg of lubricant and disintegrant. I present this illustration primarily to show that the author knows no0thing about tablet formulation;’ there is no relation between the amount of insoluble dibasic calcium phosphate and the absorption of whatever manganese is present in the tablet.
Paragraph 5 - 7) This is just hype. if these folks want to eliminate dibasic calcium phosphate from their tablets that’s fine, but it has no objectionable qualities, and some fillers are certainly necessary, as shown in the previous paragraph where the formulation contains about 75% by weight filler. if they don’t use calcium phosphates, then what do they use? other common and cheap tablet fillers are calcium sulfate, to which I would presume they might have similar objections, various sugars, starches, and flocs, dairy whey, etc. Many consumers object to these fillers for other dietary reasons. You must use something; what do they use.
Please call me if you have other questions about this. I’ve enclosed a copy of my C.V for your use so you wouldn’t think I’m as dumb as those guys.
Best Regards,
[Withheld under threat of extortion]
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Curriculum Vitae
Experience: [Some deleted to preserve privacy] The Odd Couple
Provides consulting and information services to the food, pharmaceutical and cosmetic industries in the areas of regulatory affairs, labeling, quality assurance & control, and produce development.
Vita-Fresh Vitamin Company, Inc. (1985-1986) Dedication dvdrip Thunderbolt and Lightfoot dvd
Vice President of Science & Technology for major manufacturer of vitamin supplements & OTC drugs. Reformulated major product line for enhanced sales appeal and 6-figure annual manufacturing cost saving. Created product and raw material specifications and revised operating manual and drug master file. Eight Below the movie
Technical Director. Responsible for regulatory affairs, product development, and QA & QC for this manufacturer of nutritional supplements & OTC products. Ensured compliance of formulations, labeling, advertising, sales and technical literature with appropriate laws and regulations of federal and state authorities.
Abbot Laboratories, Diagnostics Division (1972 - 1985)
QA/QC for manufacturer of in vitro diagnostic reagents. analytical methods development, stability operating procedures, GMP audits, etc.
Education:
B.S. Chemistry, Stanford University 1966. Independent research on preparative ruthenium chemistry with Prof. Henry Taube, 183 Nobel laureate.
PhD Inorganic Chemistry, Penn State University 1973. Dissertation: “Electronic & Molecular Structures of Platinum Group Aquochloro & Chlorocarbonyl Complexes”
Member:
American Chemical Society
American Association of Pharmaceutical Scientists
Institute of Food Technologists