Feed on Posts or Comments 04 July 2008

Uncategorized admin on 03 Jul 2008

Facts To Remember About DCP

In spite of its industry-wide use, DCP:

  • is non-hygroscopic by nature (will not absorb water).  This makes it nearly “insoluble” by those with a limited supply of hydrochloric acid (HCl).   When sufficient HCl is present, the DCP tablets will break down; however, they can contribute to soft tissue calcification.
  • contains inorganic calcium; not the best sources of the element.
  • is cited as a possible cause of kidney stones
  • is an alkalizer which could neutralize hydrochloric acid and conceivably hinder the absorption of minerals.
  • is a mineral antagonist, particularly with such elements as manganese.

The most common kidney stones are made of calcium oxalate, a hard salt compound, or calcium oxalate mixed with calcium phosphate.  It appears that 70 to 80 percent of kidney stones are made of these calcium salts.  In The Kidney Stones Handbook, author Gail Colomb mentions that taking calcium-based supplements can increase the chance of stone formation in some people.

Uncategorized admin on 03 Jul 2008

The Origin of DCP

Mined from deposits within the earth’s crust, calcium phosphate is known by many synonyms such as “lime,” “hardware lime,” “calcium lime” or “dolomite.”  Mixed samples of the substance may have a high percentage of impurities imbedded in them which may be harmful.  For instance, one of the compounds found in DCP may be lead.  Dolomite, in particular, has been singled out as containing a high percentage of lead.While we refer to DCP as Di-Calcium Phosphate, the term is used broadly to include all forms of calcium phosphate.  Some deposits may be slightly higher proportionately as regards to particular ingredients.  Whatever the differences, all are considered forms of calcium phosphate and act metabolically in a similar manner.

Feed Additives admin on 01 Apr 2008

Choline Chloride

Choline chloride or 2-hydroxy-N,N,N-trimethylethanaminium chloride is an organic compound and a quaternary ammonium salt. The counterion is chloride. In the laboratory choline can be prepared by methylation of dimethylethanolamine with methyl chloride. In the industrial Davy process choline chloride is produced from ethylene oxide, hydrochloric acid, and trimethylamine. Alternative names are hepacholine, biocolina and lipotril.

Choline chloride is mass produced and is an important additive in feed especially for chicken where it accelerates growth. With urea it forms a deep eutectic solvent. Other commercial choline salts are choline hydroxide and choline bitartrate. In foodstuffs the compound is often present as phosphatidylcholine.

Food Additives & Pharmaceutical Raw Materials admin on 27 Mar 2008

Mannitol

Mannitol is used for:

Preventing or treating excess body water in certain kidney conditions, reducing swelling of the brain, or reducing pressure in the eye. It may also be used for other conditions as determined by your doctor.

Mannitol is an osmotic diuretic. It works by increasing the amount of fluid excreted by the kidneys and helps the body to decrease pressure in the brain and eyes.

Do NOT use Mannitol if:

  • you are allergic to any ingredient in Mannitol
  • you have a history of heart failure
  • you have decreased or absent production of urine due to severe kidney disease, certain severe lung problems (eg, pulmonary congestion or pulmonary edema), bleeding in the brain, or severe dehydration

Contact your doctor or health care provider right away if any of these apply to you.

Before using Mannitol :

Some medical conditions may interact with Mannitol . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have swelling, kidney problems, or heart problems (eg, congestive heart failure)

Some MEDICINES MAY INTERACT with Mannitol . However, no specific interactions with Mannitol are known at this time.

Ask your health care provider if Mannitol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Mannitol :

Use Mannitol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Mannitol is usually administered as an injection at your doctor’s office, hospital, or clinic.
  • If Mannitol contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Mannitol , contact your doctor right away.

Ask your health care provider any questions you may have about how to use Mannitol .

Important safety information:

  • Mannitol may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Mannitol with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Tell your doctor immediately if you have difficulty urinating or experience extreme dizziness.
  • Lab tests, including blood electrolytes, kidney function, lung function, heart function, and blood counts, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Mannitol with caution in the ELDERLY; they may be more sensitive to its effects.
  • Mannitol should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is not known if Mannitol can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Mannitol while you are pregnant. It is not known if Mannitol is found in breast milk. If you are or will be breast-feeding while you use Mannitol , check with your doctor. Discuss any possible risks to your baby.

Proper storage of Mannitol :Mannitol is usually handled and stored by a health care provider. If you are using Mannitol at home, store Mannitol as directed by your pharmacist or health care provider. Keep Mannitol out of the reach of children and away from pets.

General information:

  • If you have any questions about Mannitol , please talk with your doctor, pharmacist, or other health care provider.
  • Mannitol is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

Pharmaceutical Raw Materials admin on 24 Mar 2008

Captopril

Why is this medication prescribed?   

Captopril is used to treat high blood pressure and heart failure. It decreases certain chemicals that tighten the blood vessels, so blood flows more smoothly and the heart can pump blood more efficiently.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

How should this medicine be used?   

Captopril comes as a tablet to take by mouth. It is usually taken two or three times a day on an empty stomach, 1 hour before or 2 hours after a meal. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take captopril exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Captopril controls high blood pressure and heart failure but does not cure them.

Continue to take captopril even if you feel well. Do not stop taking captopril without talking to your doctor.

What special precautions should I follow?   

Before taking captopril,

  • tell your doctor and pharmacist if you are allergic to captopril or any other drugs.
  • tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially diuretics (’water pills’), lithium (Eskalith, Lithobid), other medications for high blood pressure, potassium supplements, and vitamins.
  • tell your doctor if you have or have ever had heart or kidney disease or diabetes.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking captopril.

What special dietary instructions should I follow?   

Talk to your doctor before using salt substitutes containing potassium. If your doctor prescribes a low-salt or low-sodium diet, follow these instructions carefully.

What should I do if I forget a dose?   

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?   

Captopril may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • dizziness or lightheadedness
  • salty or metallic taste, or decreased ability to taste
  • cough
  • sore throat
  • fever
  • mouth sores
  • unusual bruising
  • fast heartbeat
  • excessive tiredness

If you experience any of the following symptoms, call your doctor immediately:

  • chest pain
  • swelling of the face, eyes, lips, tongue, arms, or legs
  • difficulty breathing or swallowing
  • fainting
  • rash

What storage conditions are needed for this medicine?  

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose   

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

What other information should I know?  

Keep all appointments with your doctor and the laboratory. Your blood pressure should be checked regularly to determine your response to captopril.

Captopril tablets may have a slight sulfur odor (like rotten eggs).

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Pharmaceutical Raw Materials admin on 11 Mar 2008

Amoxicillin

What is amoxicillin?

Amoxicillin is an antibiotic in the penicillin group of drugs. It fights bacteria in your body.

Amoxicillin is used to treat many different types of infections caused by bacteria, such as ear infections, bladder infections, pneumonia, gonorrhea, and E. coli or salmonella infection. Amoxicillin is also sometimes used together with another antibiotic called clarithromycin (Biaxin) to treat stomach ulcers caused by Helicobacter pylori infection. This combination is sometimes used with a stomach acid reducer called lansoprazole (Prevacid).

Amoxicillin may also be used for other purposes not listed in this medication guide.

Important information about amoxicillin

Do not use this medication if you are allergic to amoxicillin or to any other penicillin antibiotic, such as ampicillin (Omnipen, Principen), carbenicillin (Geocillin), dicloxacillin (Dycill, Dynapen), oxacillin (Bactocill), penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids), and others.

Before using amoxicillin, tell your doctor if you are allergic to cephalosporins such as Ceclor, Ceftin, Duricef, Keflex, and others. Also tell your doctor if you have asthma, liver or kidney disease, a bleeding or blood clotting disorder, mononucleosis (also called “mono”), or any type of allergy.

Amoxicillin can make birth control pills less effective, which may result in pregnancy. Before taking amoxicillin, tell your doctor if you use birth control pills. Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Amoxicillin will not treat a viral infection such as the common cold or flu. Do not give this medication to another person, even if they have the same symptoms you do.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Uncategorized admin on 19 Dec 2007

Sunlight Helps Put Lung Cancer in the Shade (The more rays people caught, the less prone they were to get the disease, study found)

U.S. National Library of Medicine MONDAY, Dec. 17 (HealthDay News) — Something as common and available as sunlight may help prevent some lung cancers, researchers say.

A new study finds that lower levels of the sun’s ultraviolet B (UVB) rays are associated with a higher incidence of lung cancer across 111 countries.

Still, that doesn’t mean that spending more time in the sun will ever offset the risks that come with smoking, according to the study, which is published in the January issue of the Journal of Epidemiology and Community Health.

It’s also not an excuse to trade skin cancer for lung cancer.

“The problem is that people might over-interpret this and stay in the sun for hours,” said Cedric Garland, study senior author, professor of family and preventive medicine at the University of California, San Diego (UCSD), and participating member at the Moores UCSD Cancer Center in La Jolla.

Too little sun isn’t great either, however, since sunlight helps the skin manufacture healthy vitamin D. “It would be false prudence to stay out of the sun to prevent skin cancer and not get enough vitamin D,” Garland said.

Other experts, however, feel the focus should stay on cigarette smoking as the number one cause of lung cancer.

“When you have such a strong factor as tobacco, it really weighs out all these other small influences,” said Dr. Jay Brooks, chairman of hematology/oncology at the Ochsner Health System in Baton Rouge, La. “It’s a very interesting observation, but the main message is tobacco is such a strong influence in the development of lung cancer that we should concentrate on that.”

More than one million people die of lung cancer worldwide each year. Cigarette smoking causes about 85 percent of lung cancers. The remaining cases are caused by exposure to secondhand smoke and a variety of other (some unknown) factors.

Sunshine is a significant source of vitamin D, as the sun’s UV rays trigger synthesis of vitamin D in the skin.

Previous research, much of it by the same group, has found a strong association between breast cancer, colon cancer and other internal-organ cancers and living in latitudes with less sunlight. For example, one paper observed double the death rate from colon cancer above the U.S. Mason-Dixon line as below, leading the researchers to focus on lack of sunlight as the culprit.

It wasn’t a new idea. “There were people in epidemiology dating back to Hippocrates who thought it was a good idea to live on the south side of a hill,” Garland said.

Another study linked lower levels of a vitamin D metabolite in the blood with a higher level of colon cancer.

For this study, Garland and his colleagues looked at the association between latitude and exposure to UVB light and rates of lung cancer in 111 countries. Data came from an extensive United Nations database.

Although smoking showed the strongest association with lung cancer, exposure to UVB light also had an impact.

UVB light is greatest closer to the equator. This study showed that lung cancer rates were highest in regions farthest away from the equator and lowest in those regions nearest to it.

Higher cloud cover and aerosol use (both of which absorb UVB rays) were linked with higher rates of lung cancer.

For men, smoking was associated with higher rates of lung cancer, while greater exposure to sunlight was associated with lower rates.

For women, cigarette smoking, along with total cloud cover and aerosol levels, were associated with higher rates of lung cancer, while sunlight was again associated with lower rates.

Previous research has indicated that vitamin D may be able to stop the growth of malignant tumors.

“Everyone should be taking vitamin D, and, at all latitudes, there’s plenty of potential to make vitamin D,” Garland said. “Even in Helsinki, people can take advantage of the sun in summer months.”

And vitamin D produced in the summer will carry over into the winter. Even so, unless you know what your vitamin D levels are, it might be wise to take a supplement, Garland advised.

Food Additives admin on 13 Dec 2007

What foods provide vitamin B6?

Vitamin B6 is found in a wide variety of foods including fortified cereals, beans, meat, poultry, fish, and some fruits and vegetables [1,11]. The table of selected food sources of vitamin B6 suggests many dietary sources of B6.

Table of Food Sources of Vitamin B6 [11]

Food Milligrams (mg)
per serving
% DV*
Ready-to-eat cereal, 100% fortified, ?c 2.00 100
Potato, Baked, flesh and skin, 1 medium 0.70 35
Banana, raw, 1 medium 0.68 34
Garbanzo beans, canned, ?c 0.57 30
Chicken breast, meat only, cooked, ?breast 0.52 25
Ready-to-eat cereal, 25% fortified, ?c 0.50 25
Oatmeal, instant, fortified, 1 packet 0.42 20
Pork loin, lean only, cooked, 3 oz 0.42 20
Roast beef, eye of round, lean only, cooked, 3 oz 0.32 15
Trout, rainbow, cooked, 3 oz 0.29 15
Sunflower seeds, kernels, dry roasted, 1 oz 0.23 10
Spinach, frozen, cooked, ?c 0.14 8
Tomato juice, canned, 6 oz 0.20 10
Avocado, raw, sliced, ?cup 0.20 10
Salmon, Sockeye, cooked, 3 oz 0.19 10
Tuna, canned in water, drained solids, 3 oz 0.18 10
Wheat bran, crude or unprocessed, ?c 0.18 10
Peanut butter, smooth, 2 Tbs. 0.15 8
Walnuts, English/Persian, 1 oz 0.15 8
Soybeans, green, boiled, drained, ?c 0.05 2
Lima beans, frozen, cooked, drained, ?c 0.10 6
* DV = Daily Value. DVs are reference numbers based on the Recommended Dietary Allowance (RDA). They were developed to help consumers determine if a food contains a lot or a little of a specific nutrient. The DV for vitamin B6 is 2.0 milligrams (mg). The percent DV (%DV) listed on the nutrition facts panel of food labels tells you what percentage of the DV is provided in one serving. Percent DVs are based on a 2,000 calorie diet. Your Daily Values may be higher or lower depending on your calorie needs. Foods that provide lower percentages of the DV also contribute to a healthful diet.

Food Additives admin on 06 Dec 2007

Strong Market of Vitamin B6

For the keeping rising price of raw material alcohol, alanine and oxalic acid, the market of Vitamin B6 has been in an upward tendency for some time. Actually, the price will be quickly increased by at least $0.5/kg since now. Hereby notify.

Pharmaceutical Raw Materials admin on 06 Dec 2007

Aspirin

Aspirin is used for:

Treatment of aches and pains associated with headache, common cold, and sore throat and for reduction of fever. It may be used to reduce the risk of death and lessen the damaging effects of an acute heart attack. It is also used to reduce the risk of heart attacks and strokes in certain men and women who have already had a heart attack or ischemic stroke. It may also be used for other conditions as determined by your doctor.

Aspirin is a nonsteroidal anti-inflammatory drug (NSAID). It works by inhibiting several different chemical processes within the body that cause pain, inflammation, and fever. It also reduces the tendency for blood to clot.

Do NOT use Aspirin if:

  • you are allergic to any ingredient in Aspirin
  • you are a child or teenager with influenza (flu) or chickenpox
  • you have bleeding problems such as hemophilia, von Willebrand disease, or low blood platelets
  • you have active severe bleeding
  • you have had a severe allergic reaction (eg, severe rash, hives, breathing difficulties, dizziness), to aspirin, salicylates (eg, salsalate), tartrazine, or an NSAID (eg, ibuprofen, naproxen, celecoxib)
  • you are taking citrate salts (eg, calcium citrate) or mycophenolate
  • Before Using Aspirin:

    Some medical conditions may interact with Aspirin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

    • if you are pregnant, plan to become pregnant, or are breast-feeding
    • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
    • if you have allergies to medicines or other substances
    • if you have alcoholism or if you consume 3 or more alcohol containing drinks every day
    • if you have asthma, bleeding or clotting problems, growths in the nose (nasal polyps), hives, kidney or liver problems, heart problems, high blood pressure, stomach or intestinal problems (eg, ulcer, inflammation), heartburn, upset stomach, stomach pain, the flu, chickenpox, or vitamin K deficiency
    • if you have high levels of calcium, aluminum, or magnesium in your blood
    • if you are a child with a stroke, a weakened blood vessel (cerebral aneurysm) or bleeding in the brain, arthritis (rheumatic disease), or Kawasaki syndrome (a rare inflammation causing heart problems in children)
    • if you have had your tonsils out or you have had oral (eg, mouth) surgery within the past 7 days

    Some MEDICINES MAY INTERACT with Aspirin . Tell your health care provider if you are taking any other medicines, especially any of the following:

    • Carbonic anhydrase inhibitors (eg, acetazolamide) because they may decrease Aspirin ’s effectiveness
    • Anticoagulants (eg, heparin, warfarin), clopidogrel, dicumarol, or nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, celecoxib) because the risk of their side effects, including risk of bleeding, may be increased by Aspirin
    • Insulin and oral antidiabetics (eg, glyburide, nateglinide) because the risk of their side effects, including low blood sugar (eg, hunger, shakiness or weakness, dizziness, headache, sweating), may be increased by Aspirin
    • Citrate salts (eg, calcium citrate) because the risk of toxicity may be increased
    • Methotrexate or valproic acid because the risk of their actions and side effects may be increased by Aspirin
    • Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), diuretics (eg, furosemide), mycophenolate, penicillamine, probenecid, sulfinpyrazone, or thyroid hormones (eg, levothyroxine) because their effectiveness may be decreased by Aspirin

    This may not be a complete list of all interactions that may occur. Ask your health care provider if Aspirin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.